Showing posts with label Vitamin D. Show all posts
Showing posts with label Vitamin D. Show all posts

Vitamin D RDA Too Low, by Ten Fold




vitaminD copyA calculation error may have skewed the vitamin D recommendations by the National Academy of Sciences (NAS),  Institute of Medicine (IOM). They are far too low, by a factor of ten, say researchers at UC San Diego and Creighton University. Researchers submitted a letter of challenge, published in the journalNutrients, which confirmed a calculation error that was also noted by other investigators using a data set from a different population.
Dr. Cedric F. Garland, Dr.P.H., adjunct professor at UC San Diego’s Department of Family Medicine and Public Health said his group confirmed findings published by Dr. Paul Veugelers from the University of Alberta School of Public Health, which were reported last October in the same journal.
“Both these studies suggest that the IOM underestimated the requirement substantially,” said Garland. “The error has broad implications for public health regarding disease prevention and achieving the stated goal of ensuring that the whole population has enough vitamin D to maintain bone health.”
The recommended intake of vitamin D specified by the IOM is 600 IU/day through age 70 years, and 800 IU/day for older ages. “Calculations by us and other researchers have shown that these doses are only about one-tenth those needed to cut incidence of diseases related to vitamin D deficiency,” Garland explained.
Robert Heaney, M.D., of Creighton University, wrote: “We call for the NAS-IOM and all public health authorities concerned with transmitting accurate nutritional information to the public to designate, as the RDA, a value of approximately 7,000 IU/day from all sources.” Garland noted, “This intake is well below the upper level intake specified by IOM as safe for teens and adults, 10,000 IU/day.”
References:
1. Heaney, R.P. et al. 2015. Letter to Veugelers, P.J. and Ekwaru, J.P., A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D. Nutrients 2014, 6, 4472–4475; doi:10.3390/nu6104472 URL: http://www.mdpi.com/2072-6643/7/3/1688
2. Veugelers, P.J. et al. 2014. A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D. Nutrients 2014, 6(10), 4472-4475; doi:10.3390/nu6104472 URL:http://www.mdpi.com/2072-6643/6/10/4472/htm.

Selections from Natural Health News (top 4 of 30+)
Jul 13, 2010
The researchers from Finland's National Institute for Health and Welfare measured vitamin D levels from the study group between 1978 and 1980, using blood samples. They then followed these people over 30 years to see ...
Dec 14, 2010
The latest controversy that has spun out of the new Vitamin D RDA announcement has caused some people to turn away from this important vitamin. But that could put them at risk of low Vitamin D and the Vitamin D Deficiency ...
May 20, 2011
Vitamin D (actually, a hormone) appears to play a wide variety of roles in health and disease. Back in 2007 I reported on a study which found that higher levels of vitamin D were associated with better physical functioning in ...
May 19, 2010
Not only do older people require more vitamin D, but so do people of color, people who do not go in the sun, those wearing clothing that fully covers the body from head to toe, but those dealing with obesity (this group may ..
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How big is the bang from osteoporosis drugs?

From Susan Brown, PhD



Answering the question “how big is the bang from osteoporosis drugs?” can be quite challenging.
One reason is that the statistical calculations are complex and highly manipulated making them difficult to understand. Another is that the subjects included in the drug studies are generally highly-selected and may not represent “real-world” populations.
Recently scientists took an important step to help us separate hype from reality in regard to the benefits of bone drugs.
Researchers asked if “real-world” patients taking bone drugs received the same fracture-reduction benefits seen in the clinical trials. After analysis of hundreds of studies, they found that highly compliant, “real world” patients on osteoporosis drugs experienced a 21% reduction in all clinical fractures. This compares to the 24% overall clinical fracture reduction experienced by subjects in osteoporosis drug clinical trials.
What a different messages than we often hear — such as how bone drugs reduce your chance of fracture by 50%! Or have you ever been told that the fracture reduction on bone drugs is really more like 21-24%? That is — if you use the drug faithfully.
Now compare this 21-24% fracture-reduction benefit from bone drugs to the studies documenting that those taking vitamin D in any dose (much less a therapeutic dose) experience a 23-26% reduction in fractures. It seems to me that the bang from osteoporosis drugs isn’t quite as big as we’ve been led to believe.
As your bone health advocate, I congratulate these researchers on the enormous effort to analyze and synthesize data from hundreds of studies. I also congratulate the drug company which funded this study for clarifying the real fracture/reduction benefit of today’s bone drugs.

References:
Wilkes, et al. 2010. “Bisphosphonates and osteoporotic fractures: a cross-design synthesis of results among compliant/persistent postmenopausal women in clinical practice versus randomized controlled trials.” Osteoporosis International 21:679-688
Bischoff-Ferrari, HA et al. 2005. Fracture prevention with vitamin D supplementation: A meta-analysis of randomized controlled trials. JAMA, 293(18): 2257-2264

The Week in Bone Health | How big is the bang from osteoporosis drugs?


Selections from Natural Health News

Sep 06, 2011
The osteoporosis drug zoledronic acid (Reclast) should not be used in patients with significant renal impairment, and physicians should screen patients for kidney dysfunction before starting them on the drug, the FDA said. ...
Aug 16, 2009
Another Big PhARMA fiasco, as all the current osteoporosis drugs seem to be. Of course you don't hear too much about their fluoride content and how this damages the thyroid and bone health, but then how would they mask ...
Oct 02, 2009
Osteoporosis drug Forteo linked with bone cancer. BLACK BOX WARNING FOR FORTEO, a gentically engineered pharmaceutical. POTENTIAL RISK OF OSTEOSARCOMA: In male and female rats, teriparatide caused an ...
Jan 24, 2009
***Just remember that as bone density leads to brittle bones and fracture, so do the prescription osteoporosis drugs. ... Part of this missing link is the bone-damaging impact from many non-osteoporosis drugs. Another is that ...
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